Vibrio natriegens with Xtreme Protein Expression and Secretion System Optimization
Vibrio natriegens is challenging Escherichia coli as the organism of choice for research and biotechnology applications – and we’re betting on V. natriegens! The gram-negative marine bacteria with a generation under 10 minutes combined with the ability to produce and secrete large amounts of proteins into the growth medium makes V. natriegens an ideal chassis organism.
Inspired by the possibilities that V. natriegens offers, our team Aalto-Helsinki is determined to take on the challenge of improving the bacterium’s protein expression and secretion.
Recombinant proteins are widely used for biomedical research and in the pharmaceutical industry. Several methods for protein production have been established during the past decades providing aid for millions of people. However, even with today’s technologies, improved efficacy is urgent as the demand for recombinant proteins is only increasing - it has been estimated that within the next 10 years half of all medicine will be biopharmaceutical, including recombinant proteins.
Our iGEM project aims to tackle these challenges by improving the next-generation synthetic biology chassis organism Vibrio natriegens. Hence the name of our project VibXPresso - Vibrio natriegens with Xtreme PRotein Expression and Secretion Optimization.